T memory stem cell characteristics in autoimmune diseases and their promising therapeutic values

Memory T cells are conventionally subdivided into central memory (T CM ) and effector EM cells. However, a new subset of named stem cell SCM has been recognized that possesses capabilities both including lymphoid homing performing roles through secretion cytokines such as interleukin-2 (IL-2) interferon-gamma (IFN-γ). The some biological properties stemness, antigen independency, high proliferative potential, signaling pathway lipid metabolism. On the other hand, considered one principal culprits in pathogenesis autoimmune diseases. responsible for developing long-term defensive immunity against different foreign antigens, alongside tumor-associated which mainly derive from self-antigens. Hence, antigen-specific can produce antitumor responses potentially able to trigger activities. Therefore, we reviewed recent evidence on functions disorders type 1 diabetes, systemic lupus erythematosus, rheumatoid arthritis, acquired aplastic anemia, immune thrombocytopenia, uveitis. We also introduced lineage an innovative prognostic biomarker promising therapeutic target settings.